英國(guó)科學(xué)家提供食管腺癌克隆型擴(kuò)散模型的證據(jù)
英國(guó)劍橋大學(xué)Rebecca C. Fitzgerald和牛津大學(xué)David C. Wedge研究組的研究，在基因組水平發(fā)現(xiàn)支持轉(zhuǎn)移性食管腺癌克隆型擴(kuò)散模型的證據(jù)。相關(guān)論文在線發(fā)表在2020年1月6日的《自然—遺傳學(xué)》上。
研究人員通過對(duì)來自18位患有EAC患者的388個(gè)樣品全基因組測(cè)序和系統(tǒng)發(fā)育分析發(fā)現(xiàn)，在90％的患者中，來自原位瘤的多個(gè)亞克隆從原發(fā)部位非常迅速地?cái)U(kuò)散，并形成了包括淋巴結(jié)和遠(yuǎn)處組織在內(nèi)的多個(gè)轉(zhuǎn)移灶–這種傳播方式被稱為“克隆型擴(kuò)散”。研究人員在尸檢中發(fā)現(xiàn)，從較早的時(shí)間點(diǎn)開始，組織和血液樣本中就已經(jīng)存在轉(zhuǎn)移性亞克隆。這些發(fā)現(xiàn)豐富了人類對(duì)EAC的理解并且對(duì)臨床評(píng)估也具有重要意義。
據(jù)悉，食管腺癌（EAC）的低治愈性促使科學(xué)家對(duì)其轉(zhuǎn)移方式和擴(kuò)散時(shí)機(jī)的研究。
附：英文原文
Title: Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma
Author: Ayesha Noorani, Xiaodun Li, Martin Goddard, Jason Crawte, Ludmil B. Alexandrov, Maria Secrier, Matthew D. Eldridge, Lawrence Bower, Jamie Weaver, Pierre Lao-Sirieix, Inigo Martincorena, Irene Debiram-Beecham, Nicola Grehan, Shona MacRae, Shalini Malhotra, Ahmad Miremadi, Tabitha Thomas, Sarah Galbraith, Lorraine Petersen, Stephen D. Preston, David Gilligan, Andrew Hindmarsh, Richard H. Hardwick, Michael R. Stratton, David C. Wedge, Rebecca C. Fitzgerald
Issue&Volume: 2020-01-06
Abstract: The poor outcomes in esophageal adenocarcinoma (EAC) prompted us to interrogate the pattern and timing of metastatic spread. Whole-genome sequencing and phylogenetic analysis of 388 samples across 18 individuals with EAC showed, in 90% of patients, that multiple subclones from the primary tumor spread very rapidly from the primary site to form multiple metastases, including lymph nodes and distant tissues—a mode of dissemination that we term ‘clonal diaspora’. Metastatic subclones at autopsy were present in tissue and blood samples from earlier time points. These findings have implications for our understanding and clinical evaluation of EAC.
DOI: 10.1038/s41588-019-0551-3
Source: https://www.nature.com/articles/s41588-019-0551-3
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